The Endo-Cannabinoid System

What is our Endo-Cannabinoid System?

Remember back in elementary school when they teach you about our body systems and they briefly mention the endocannabinoid system? I always remember trying to say that word as a youngin and always laughing at myself. Come to find out this ends cannabinoid system would play such a large role in my life quite literally and figuratively.

Lets take a quick dive into the basics of our endo-cannbinoid system. Our Endo-Cannabinoid System includes our appetite, immune system, pain management, sleep, memory and our emotional state as human beings. We have two primary endocannabinoid receptors have been identified: CB1, first cloned in 1990; and CB2, cloned in 1993. CB1 receptors are found predominantly in the brain and nervous system, as well as in peripheral organs and tissues, and are the main molecular target of the endocannabinoid lingad (binding molecule), anadamine, as well as its mimetic phytocannabinoid,THC. One other main endocannabinoid is 2-Arachidonoylglycerol (2-AG) which is active at both cannabinoid receptors, along with its own mimetic phytocannabinoid, CBD. 2-AG and CBD are involved in the regulation of appetite, immune system functions and pain management.

The endocannabinoid system (ECS) is a group of endogenous cannabinoid receptors located in the mammalian brain and throughout the central and peripheral nervous systems, consisting of neuromodulatory lipids and their receptors. Known as "the body’s own cannabinoid system" the ECS is involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory, and in mediating the psychoactive effects of cannabis. The ECS is also involved in voluntary exercise and may be related to the evolution of the runner's high in human beings and related aspects of motivation or reward for locomotor activity in other animals. Recent studies from the UK and Israel have shown that there are around 140 + cannabinoid receptors in our body.

Homeostasis is the concept that most biological systems are actively regulated to maintain conditions within a narrow range. Our body doesn’t want its temperature to be too hot or too cold, blood sugar levels too high or too low, and so on. Conditions need to be just right for our cells to maintain optimum performance, and exquisite mechanisms have evolved to draw them back to the Goldilocks zone if they move out. The body’s endocannabinoid system (ECS) is a vital molecular system for helping maintain homeostasis—it helps cells stay in their Goldilocks zone.

CB1-

The cannabinoid receptor type 1, often abbreviated as CB1, is a G protein-coupledcannabinoid receptor located primarily in the central and peripheral nervous system. It is activated by the endo-cannabinoid neurotransmitters anandamide and 2-arachidonoylglycerol (2-AG); also active by plant cannabinoids, such as the compound THC, an active ingredient of the psychoactive drug cannabis; and by synthetic analogues of THC. CB1 and THC are deactivated by the phytocannabinoid tetrahydrocannabivarin (THCV).

CB2-

>he cannabinoid receptor type 2, abbreviated as CB2, is a G protein-coupled receptor from the cannabinoid receptor family that in humans is encoded by the CNR2 gene. It is closely related to the cannabinoid receptor type 1, which is largely responsible for the efficacy of endocannabinoid-mediated presynaptic-inhibition, the psychoactive properties of tetrahydrocannabinol, the active agent in cannabis, and other phytocannabinoids (plant cannabinoids). The principal endogenous ligand for the CB2 receptor is 2-arachidonoylglycerol (2-AG). CB2 was cloned in 1993 by a research group from Cambridge looking for a second cannabinoid receptor that could explain the pharmacological properties of tetrahydrocannabinol. The receptor was identified among cDNAs based on its similarity in amino-acid sequence to the cannabinoid receptor type 1 (CB1) receptor, discovered in 1990. The discovery of this receptor helped provide a molecular explanation for the established effects of cannabinoids on the immune system.

ECS is pretty much all that we are made up of. We naturally produce it and we need CBDs in our system daily just as we are told to take Vitamin C, Zinc, Magnesium, Calcium and much more. We NEED this in our daily lives.,

Different receptors for different compounds link to different receptor points:

  • CBGA (Cannabigerolic acid)
  • THCA (Δ9-tetrahydrocannabinolic acid)
  • CBDA (Cannabidiolic acid)
  • CBCA (Cannabichromenenic acid)
  • CBGVA (Cannabigerovarinic acid)
  • THCVA (Tetrahydrocanabivarinic acid)
  • CBDVA (Cannabidivarinic acid)
  • CBCVA (Cannabichromevarinic acid)